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Systematic review with meta analysis
In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery
  1. Christoph Bührer
  1. Department of Neonatology, Charité University Medical Center Berlin, Berlin, Germany
  1. Correspondence to : Professor Christoph Bührer, Klinik für Neonatologie, Charité Universitätsmedizin Berlin, Berlin D-13344, Germany; christoph.buehrer{at}

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Treating and preventing pain is imperative for physicians caring for newborn infants, as it is everywhere else in clinical medicine. In patients of this age group, the efficacy of analgesic medications is difficult to assess. Opioids are the drugs of choice to treat severe pain, but their most common side effect, respiratory depression, evokes reluctance to administer opioids to non-ventilated newborn infants outside the setting of a neonatal intensive care unit. Paracetamol (acetaminophen) is devoid of respiratory side effects and a popular drug for children and adults with pain or fever. This is the …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.