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Randomised controlled trial
Physical, nutritional, cognitive and combination interventions reduce frailty in community-dwelling prefrail and frail older people
  1. Nicola Fairhall
  1. The George Institute for Global Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia
  1. Correspondence to : Dr Nicola Fairhall, The George Institute for Global Health, PO Box M201, Missenden Rd, NSW 2050 Australia; nfairhall{at}

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Frailty is a common and costly problem. Recent research has enhanced our understanding of the aetiology, diagnosis and impact of frailty, yet the next step is to identify and evaluate interventions that target remediable aspects of frailty. Preventing frailty in people who are prefrail and ameliorating frailty in those already frail, has the potential to reduce poor health outcomes associated with frailty, such as disability, falling, hospitalisation and institutionalisation. To date, few studies have specifically recruited frail individuals or targeted frailty as an outcome. This study examined the effect of four intervention programmes versus usual care on degree of frailty in older people.


This was a randomised controlled trial conducted in community-dwelling prefrail and frail volunteers aged 65 years …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.