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Delirium is a form of ‘acute brain dysfunction’ characterised by fluctuations in consciousness, attention and cognitive function.1 Delirium often results from the confluence of multiple factors related to severe acute illness including inflammation, neurotransmitter imbalances, blood-brain barrier disruption, loss of cerebrovascular autoregulation, metabolic insults, oxidative stress, sedative medications and disruption of sleep/wake cycle.2 ,3 It is therefore unsurprising that delirium is highly prevalent during critical illness, affecting up to 80% of patients requiring intensive care, with associated prolonged mechanical ventilation, long-term cognitive impairment and potentially, mortality.4 ,5 Litton et al performed a …
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Contributors AJW and ACL contributed to the conceptualization and drafting of the manuscript. AJW was responsible for final approval of the contents of the manuscript.
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.