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Therapeutics/Prevention
Randomised controlled trial
Antibiotics of no benefit to children with eczema and features of cutaneous infection but controversy remains unresolved
  1. Ting Fan Leung
  1. Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong
  1. Correspondence to: Professor Ting Fan Leung, Department of Paediatrics, The Chinese University of Hong Kong, Room 84043, Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong; tfleung{at}cuhk.edu.hk

https://doi.org/10.1136/ebmed-2016-110457

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    Commentary on: Francis NA, Ridd MJ, Thomas-Jones E, et al. A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: the ChildRen with Eczema, Antibiotic Management (CREAM) study. Health Technol Assess 2016;20:1–84OpenUrl.

    Context

    Eczema poses substantial adverse impact on the quality of life of patients and their families. Although most patients have cutaneous Staphylococcus aureus colonisation,1 the relationship between S. aureus and eczema flares remains unclear.2 Oral and topical antibiotics are widely prescribed to treat clinically infected eczema despite the lack of high-quality evidence to justify this practice. This multicentre randomised, double-blind, placebo-controlled trial (RDBPCT) examined whether antibiotics confer benefits to these patients.

    Methods

    The ChildRen with Eczema, …

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    Footnotes

    • Competing interests None declared.

    • Provenance and peer review Commissioned; internally peer reviewed.