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Randomized controlled trial
Diet–heart disease hypothesis is unaffected by results of analysis of recovered data from Minnesota Coronary Experiment
  1. C Murray Skeaff,
  2. Jim I Mann
  1. Department of Human Nutrition, University of Otago, Dunedin, New Zealand
  1. Correspondence to: Professor Murray Skeaff, Department of Human Nutrition, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand; murray.skeaff{at}

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Replacement of a proportion of saturated fat with polyunsaturated fats is a cornerstone of dietary recommendations for the prevention of coronary heart disease.1 Ramsden and colleagues have hypothesised that n-6 polyunsaturates may increase the risk of heart disease.2

The Minnesota Coronary Experiment (MCE) was one of a small number of randomised controlled trials conducted and published between the mid-1960s and early 1990s to test the effect of replacing dietary saturated fat with polyunsaturated fat on coronary heart disease.3 The relative risk of coronary events in the treatment group was 1.08 (95% CI 0.84 to 1.37) and this result, reported in the trial's original paper, has been included …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.