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Aetiology/Harm
Cohort study
Morphine exposure in preterm infants correlates with impaired cerebellar growth and poorer neurodevelopmental outcome
  1. Christopher McPherson
  1. St Louis Children's Hospital, St Louis, Missouri, USA
  1. Correspondence to : Dr Christopher McPherson, St Louis Children's Hospital, 1 Children's Place, 11th floor, St Louis, MO 63110,USA; mcpherson_c{at}kids.wustl.edu
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http://dx.doi.org/10.1136/ebmed-2016-110511

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    Commentary on: Zwicker JG, Miller SP, Grunau RE, et al. Smaller cerebellar growth and poorer neurodevelopmental outcomes in very preterm infants exposed to neonatal morphine. J Pediatr 2016;172:81–7OpenUrlCrossRefPubMed.

    Context

    Optimal care of preterm infants includes adequate treatment of pain and agitation. However, guidelines caution against the routine use of opioids in common situations such as mechanical ventilation, given the potential for respiratory adverse effects.1 Despite this caution, opioid exposure for this indication remains common.2 Conflicting data exist regarding the impact of this exposure on the developing brain.3 This prospective cohort study examines the relationship between morphine exposure in infants born very preterm and brain growth at term-equivalent age as well as neurodevelopmental outcomes at …

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