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Studies have demonstrated that caloric restriction (CR) increases longevity in animals and also decreases the risk of diabetes, cardiovascular disease and cancer in humans without obesity.1 ,2 It is hypothesised that these favourable CR effects may be related to a reduction in metabolism, reduced core temperature and lowered triiodothyronine(T3).3 While it is unlikely that studies will ascertain whether CR extends life, intermediate length studies may be able to determine the safety, tolerability and feasibility of CR and its effects on chronic disease development and biomarkers correlated with longevity.2 This study aimed to examine the sustained effects of a 25% CR on health-related quality of life (QOL) in individuals …
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.