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Of the available colorectal cancer (CRC) screening tests, only flexible sigmoidoscopy and faecal occult blood tests have been evaluated with randomized controlled trials (RCTs). Colonoscopy and faecal immunochemical tests (FITs) are commonly used for CRC screening, but RCT evidence will not be available for at least a decade.
For its 2016 CRC screening recommendation, the US Preventive Services Task Force (USPSTF) commissioned the Cancer Intervention and Surveillance Modeling Network (CISNET) to analyse 8 screening tests, in 204 screening strategies in a hypothetical cohort of US 40-year-olds, using 3 different models. Each model simulated the adenoma–carcinoma sequence with …