Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Patients with type 2 diabetes (T2D) are exposed to a high risk of cardiovascular disease (CVD) and premature mortality. A multirisk approach has proven to reduce both major cardiovascular events and mortality.1 However, improved longevity may lead to a higher risk of developing other diabetic complications, among which chronic kidney disease represents a major burden.
Inhibitors of renal sodium-glucose cotransporters type 2 (SGLT2) are oral glucose-lowering agents that promote glucosuria and dampen glucotoxicity, but also reduce body weight, arterial blood pressure and hyperuricaemia.2 By reducing these risk factors, SGLT2 inhibitors offer promise to reduce cardiovascular and renal outcomes in patients with T2D.
EMPA-REG OUTCOME aimed at investigating the effects of empagliflozin, a selective SGLT2 inhibitor, on cardiovascular morbidity and mortality in patients with T2D at high cardiovascular risk (secondary prevention) …
Competing interests AJS worked as a clinical investigator enrolling four participants in this double-blind placebo-controlled EMPA-REG OUTCOME trial.
Provenance and peer review Commissioned; internally peer reviewed.