Article Text

Download PDFPDF
Cohort study
High-dose sulphonylurea treatment in patients with renal impairment should be considered with caution
  1. Gyuri Kim,
  2. Eun Seok Kang
  1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
  1. Correspondence to: Dr Eun Seok Kang, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea; edgo{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Commentary on:


Type 2 diabetes mellitus (T2DM) is one of the most serious health problems worldwide.1 Strict glycaemic control has been emphasised, and the number of patients with the risk of hypoglycaemia has increased.2 Hypoglycaemia is a serious side effect of treatment with sulphonylureas, which stimulate insulin secretion regardless of blood glucose level. It is more common in patients using long-acting sulphonylureas with renally excreted active metabolites.3 Therefore, an increasing number of patients with renal impairment may currently live with the risk of hypoglycaemia. …

View Full Text


  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.