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In localised prostate cancer, radical prostatectomy was associated with more sexual dysfunction and urinary incontinence than radiation or active surveillance
  1. Zachary L Smith,
  2. Scott E Eggener
  1. Department of Surgery, Section of Urology, The University of Chicago Medicine, Chicago, Illinois, USA
  1. Correspondence to Dr Scott E Eggener, Department of Surgery, Section of Urology, The University of Chicago Medicine, 5841 S. Maryland Avenue, MC 6038, Chicago, IL 60637, USA; seggener{at}

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Commentary on: Barocas DA, Alvarez J, Resnick MJ, et al. Association between radiation therapy, surgery, or observation for localized prostate cancer and patient-reported outcomes after 3 years. JAMA 2017;317:1126–1140.


Widespread prostate cancer (PCa) screening has reduced PCa mortality, but also leads to overdiagnosis. After diagnosis, men are faced with a variety of management options that often have similar rates of cure but considerable risks to quality of life (QoL). The Comparative Effectiveness Analysis of Surgery and Radiation (CEASAR) study was developed to examine patient-reported outcomes measures (PROMs) after treatment for localised PCa.1


CEASAR is a prospective, longitudinal, population-based cohort study composed of patients from five Surveillance, Epidemiology, and End Results registries and the …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.