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Effect size in CANTOS trial
  1. Nanda Gamad,
  2. Nusrat Shafiq,
  3. Samir Malhotra
  1. Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
  1. Correspondence to Dr Samir Malhotra, Post Graduate Institute Medical Education and Research, Chandigarh 160012, India; smal.pgi{at}

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The primary endpoint in Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial published by Ridker et al 1 was non-fatal myocardial infarction, non-fatal stroke or cardiovascular death. The authors concluded that canakinumab 150 mg reduced primary event rates compared with placebo (3.86 vs 4.11 per 100 person-years) with HR 0.85 (95%CI 0.74 to 0.98; P=0.021). Sample …

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  • Contributors NG wrote the first draft of the letter. All three authors took the final decision and contributed in the final version.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.