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Regarding minimal clinically relevant differences for superiority margins
  1. Patrick S Phelan
  1. Washington University School of Medicine, Saint Louis, Missouri, USA
  1. Correspondence to Patrick S Phelan, Washington University School of Medicine, Saint Louis, MO 63110, USA; psphelan{at}

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Being familiar with the relevant previous work of authors Shafiq and Malhotra, I read with interest their recent letter with Gamad concerning reporting of the Canakinumab Anti-Inflammatory Thrombosis Outcome Study (CANTOS).1 That trials such as CANTOS continue to be reported with claims of superiority without consideration of asymmetry in error margins …

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  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.