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Contributors AB produced the original draft manuscript and all authors were responsible for revisions and the final version.
Competing interests AB has received honoraria from Novo Nordisk and Boehringer Ingelheim. The other authors have no competing interests to report.
Patient consent Not required.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement No data were used for this manuscript.
Presented at This manuscript was influenced by the outcomes of three workshops which AB designed and coordinated on the theme of big data in healthcare: ‘Big data and Evidence-Based Medicine-the promises and the pitfalls’ at Evidence Live, Oxford in June 2016; ‘Learning health systems-the only way to do translational data science?’ at the International Population Data Linkage Network (IPDLN) Conference, Swansea in August 2016 and ‘Big data-part of the problem of over-diagnosis or part of the solution?’ at the Preventing Overdiagnosis Conference, Barcelona in September 2016.
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