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Synthesis of case reports for meta-assessment of causality
  1. Patrick S Phelan
  1. Washington University School of Medicine, St Louis, Missouri, USA
  1. Correspondence to Patrick S Phelan, Washington University School of Medicine, St Louis, MO 63110, USA; psphelan{at}

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The evaluation tool presented by Murad and colleagues1 provides an accessible system for judging components of methodological quality in published case reports and series. Whereas the authors observe that their leading explanatory questions in the domain of causality are mostly applicable to drug-related adverse events, it is worth noting that additional, more generalisable factors have been identified. I propose that recognition of such factors offers the potential for meta-assessment of causality across reports of the same or similar interventions.

Authors Kiene, Hamre and …

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  • Funding The author has not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; internally peer reviewed.