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After describing the formal methodology for validating surrogate outcomes, Dobler and colleagues conditionally recommend that since there is convincing evidence that direct-acting agents do produce sustained viral responses (SVRs) in patients treated for chronic hepatitis C, such treatment ‘may be appropriate’.1 They did recognise that the SVR, a surrogate outcome, has never been formally validated, but they came to their recommendation anyway based on a strong association between SVRs and important clinical outcomes and a single randomised clinical trial (RCT) of debatable quality that interferon (IFN)-based …
Competing interests None declared.
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Provenance and peer review Not commissioned; internally peer reviewed.
Data sharing statement This letter does not contain any original research.
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