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Emergency care
Biomarkers of acute kidney injury: mixed results and huge heterogeneity of reporting
  1. Etienne Gayat
  1. Correspondence to Pr Etienne Gayat, Department of Anesthesiology and Critical Care, Hôpitaux Universitaires Saint Louis, Paris 75010, France; etienne.gayat{at}

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Commentary on: Hall PS, Mitchell ED, Smith AF, et al. The future for diagnostic tests of acute kidney injury in critical care: evidence synthesis, care pathway analysis and research prioritisation. Health Technol Assess. 2018;22:1–274.


Acute kidney injury (AKI) is a common condition in hospitalised patients and is associated with worse short-term and long-term outcome. The delay in the diagnosis of AKI has been proven to be associated with morbidity and mortality. One of the challenges clinicians face is the early detection of AKI. Another difficulty is the lack of a consensual definition of AKI. Expert consensus seems to be emerging,1 but recent literature review shows that the definitions used in the published articles remain multiple and heterogeneous.2 While many urinary and serum proteins have been investigated as potential biomarkers for the early diagnosis or …

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  • Contributors EG performed the critical review of the article and drafted the commentary.

  • Competing interests Consultant fees from Magnisense and Sphingotec, Research grants from Deltex Medical, Retial Medical.

  • Provenance and peer review Commissioned; internally peer reviewed.