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General medicine
Fat or fiction: the diet-heart hypothesis
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  • Published on:
    Setting the Record Straight on Saturated Fat and LDL-cholesterol. Ignorance is not bliss.
    • Richard M Fleming, Physicist-Cardiologist FHHI-OI-Camelot
    • Other Contributors:
      • Matthew R Fleming, Physicist-Paramedic
      • Tapan K Chaudhuri, MD

    Like so many purported pundits, DuBroff R, de Lorgeril M [1] have attempted to dispute the significance of the role of saturated fat (triglycerides) and LDL-cholesterol in the development of coronary artery disease, while noting the importance of inflammation itself [1,2]. In law, ignorance of the law is not a defense - the same is true for medicine. Not understanding something does not make you an expert [2] and it does not make your argument valid. Appealing to the court of public opinion does not make it so either. Accordingly, we present a brief explanation of why the authors [1,2] – and others – have presented an invalid discussion of the role fat and LDL-cholesterol plays in coronary artery disease.

    In the mid-1990s, as one of the reviewers for the American Heart Association, the first author of this letter, Dr Richard M Fleming (RMF) introduced a then controversial theory stating that Coronary Artery Disease (CAD) is the result of an inflammatory process, which builds up within the walls of the arteries impairing their ability to dilate and increase coronary blood flow when needed; thus producing regional blood flow differences resulting in angina [3-6] and ultimately myocardial infarction (MI) and death.

    In recent years, people promoting various dietary and lifestyle practices – particularly those promoting LowCarb-Keto diets, have used the obesity epidemic to focus attention on obesity and weight loss. These same individuals have not demonstrated th...

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    Conflict of Interest:
    FMTVDM (The Fleming Method for Tissue and Vascular Differentiation and Metabolism) [6] is issued to the first author. The first author authored the “Inflammation and Heart Disease” and “Angina” Theories.