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- Published on: 24 May 2022
- Published on: 24 May 2022Rapid Response, BMJ Evidence-Based Medicine
Rapid Response, BMJ Evidence-Based Medicine
Re: Popp M, Kranke P, Meybohm P, et al. Evidence on the efficacy of ivermectin for covid-19: another story of apples and oranges. BMJ Evidence-Based Medicine Published Online First: 20 August 2021. doi: 10.1136/bmjebm-2021-111791Ivermectin in Covid-19
Andrew Bryant MSc
Population Health Sciences Institute, Newcastle University
Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne NE2 4AX, UK
Email: andy.bryant@ncl.ac.uk
Theresa A Lawrie MBBCh PhD
Edmund J Fordham PhD FInstP
EbMCsquared, a Community Interest Company
Northgate House, Upper Borough Walls, Bath BA1 1RG, UK
Scott Mitchell MBChB MRCS
Emergency Department, Princess Elizabeth Hospital, GuernseyTo the Editor
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The sole substantive critique in this Letter[1] is the description of Bryant[2] et al. (hereafter “Bryant”) as a “bowl of colourful fruit salad”[1], because of the pre-specified comparison of “ivermectin” vs “no ivermectin”. Trials with (potentially) active comparators were indeed included. Reflection should show that any bias is conservatively against ivermectin. Helpful control interventions would dilute the apparent benefit of ivermectin, relative to inactive comparators exclusively. Efficacy will be understated, not overstated, with respect to controls.
Unsuspected active agents in ivermectin combination therapies might...Conflict of Interest:
Conflicts of interest: AB TAL EJF and SM are co-authors of Ref [2] attacked in the Letter [1]. They were members of the British Ivermectin Recommendation Development (BiRD) panel at the “Evidence to Decision” event convened on 20 February 2021. TAL and AB were members of the steering group and did not vote. EJF and SM were ordinary members of the panel. BiRD is a public information activity managed by EbMCsquared, a non-profit Community Interest Company funded by public donations. EJF and SM are unpaid volunteers entirely without financial interest. EJF is a member of the Health Advisory and Recovery Team (HART), an unincorporated membership association with no financial or material interests in ivermectin or any other medical product. This work, and Ref [2], are not projects of HART, and are not funded or influenced in any way by them