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Implementing hierarchical network meta-analysis incorporating exchangeable dose effects compared to standard hierarchical network meta-analysis

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  • Contributors JW, MH, SS and AAV conceptualised the study. JW, CDG, RT, DM and AAV contributed to model creation. JW performed all analyses. JW, ACT, SS and AAV supported data duration. JW drafted the first version of the manuscript and is the guarantor of this article. All authors reviewed and edited the manuscript.

  • Funding ACT is funded by a Tier 2 Canada Research Chair in Knowledge Synthesis. SES is funded by a Tier 1 Canada Research Chair in Knowledge Translation. RMT is supported by the UK Medical Research Council (grant No MC_UU_00004/06).

  • Competing interests All authors have completed the ICMJE uniform disclosure form and declare: no support from any organisation for the submitted work; no financial relationships with any organisations that might have an interest in the submitted work in the previous 3 years and no other relationships or activities that could appear to have influenced the submitted work. AAV is on the editorial board of BMJ Evidence Based Medicine but was not involved with the peer review process or decision to publish.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.