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Therapeutics
Continuous positive airway pressure was beneficial in mild sleep apnoea-hypopnoea syndrome

https://doi.org/10.1136/ebm.4.6.169

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    Engleman HM, Kingshott RN, Wraith PK, et al. Randomized placebo-controlled crossover trial of continuous positive airway pressure for mild sleep apnea/hypopnea syndrome. Am J Respir Crit Care Med. 1999 Feb;159: 461-7.

    Question

    In patients with the sleep apnoea-hy- popnoea syndrome (SAHS), does con- tinuous positive airway pressure (CPAP) therapy improve symptoms, cognitive performance, and psychological well-being?

    Design

    Randomised (unclear allocation concealment), unblinded, placebo-controlled, crossover trial with 4-week follow-up.

    Setting

    A sleep clinic in Edinburgh, Scotland.

    Patients

    37 patients with 2 symptoms of SAHS, including substantial sleepiness (Epworth sleepiness score 8 or admitted sleepiness while driving), and apnoea and hypopnoea index (AHI) of 5.0 to 14.9 per hour slept. Exclusion criteria included shift work, coexisting sleep disorders, or neurological or lung disease. 34 patients (92%) (mean age 44 y, 62% men) were included in the analysis.

    Intervention

    Patients were initially allocated to CPAP therapy or placebo (2 tablets/d) for …

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