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Slow, repetitive transcranial magnetic stimulation was effective for major depression

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Klein E, Kreinin I, Chistyakov A, et al. Therapeutic efficacy of right prefrontal slow repetitive transcranial magnetic stimulation in major depression. A double-blind controlled study. Arch Gen Psychiatry. 1999 Apr; 56:315-20.


In patients with major depression, is slow, repetitive transcranial magnetic stimulation (rTMS) effective for relieving depressive symptoms?


2-week randomised, double-blind, placebo-controlled trial.


{Psychiatric department of a general hospital}* in Israel.


70 patients (mean age 59 y, 76% women) who had major depression according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition; were right handed; had normal neurological and general physical examination results; did not have a history of major brain trauma, seizure disorder, or substance abuse; and were not medication resistant. Follow-up was 96%.


Patients were allocated to rTMS (n = 36) or sham rTMS (n = 34). In …

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