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Ofman JJ, Rabeneck L. The effectiveness of endoscopy in the management of dyspepsia: a qualitative systematic review. Am J Med. 1999 Mar;106: 335-46.
Question
Does initial endoscopy improve patient outcomes and medical decision making and reduce subsequent use of medical resources in patients with dyspepsia?
Data sources
English-language studies were identified by searching MEDLINE, HEALTH-STAR, and EMBASE/Excerpta Medica for articles from January 1985 to July 1998. Bibliographies of relevant arti- cles were reviewed, and experts were contacted.
Study selection
Clinical studies were selected if they assessed the effectiveness of endoscopy for patient outcomes, clinical decision making, resource utilization, or cost- effectiveness. Decision analyses were included if they considered initial endoscopy as a management strategy. Review articles, editorials, letters, case series, and studies of children were excluded.
Data extraction
Data were extracted on study design, patients, interventions, outcome measures, main findings, and conclusions. Individual studies were assessed for methodologic quality (i.e., inclusion and exclusion criteria, randomized design, concealment of …