Article Text

Ovarian cancer screening was feasible but did not decrease incidence of index cancer or mortality

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Jacobs IJ, Skates SJ, MacDonald N, et al. Screening for ovarian cancer: a pilot randomised controlled trial. Lancet. 1999 Apr 10;353:1207-10.

Question

In postmenopausal women, what is the feasibility and effectiveness of ovarian cancer screening?

Design

Randomised (concealed), unblinded, controlled trial with 7-year follow-up.

Setting

United Kingdom.

Participants

Women who were 45 years of age and were postmenopausal. Exclusion criteria were history of bilateral oophorectomy or ovarian cancer. 22 000 women were invited to participate; 21 935 were randomised. All participants were traced through the National Health Service Central Register and the Family Health Services Authority.

Intervention

Women were allocated to annual screening for ovarian cancer for 3 years (n = 10 958) or to follow-up with no screening (n = 10 977). Initial screening involved measuring serum CA 125 antigen. Women with CA 125 of 30 U/mL were recalled for …

View Full Text