You are here

Article Text

Article menu
Therapeutics
Radiotherapy and tamoxifen after surgery improved local control and survival in breast cancer

https://doi.org/10.1136/ebm.4.6.183

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Overgaard M, Jensen MB, Overgaard J, et al. Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Lancet. 1999 May 15; 353:1641-8.

    Question

    In postmenopausal women with breast cancer, does the addition of radiotherapy to 1 year of adjuvant tamoxifen after surgery reduce locoregional recurrence and improve survival?

    Design

    Randomised controlled trial with 10-year follow-up.

    Setting

    76 surgical departments in Denmark.

    Patients

    1460 postmenopausal women who were younger than 70 years of age and had high-risk breast cancer (node positive, tumour size > 5 cm, invasion to skin or pectoral fascia, or any combination of these characteristics). Exclusion criteria were metastatic distant disease, previous or concomitant other malignant disease, or macroscopic residual tumour. 1375 patients (94%) (median age 62 y) were included in the analysis.

    Intervention

    All patients had had total mastectomy and limited axillary dissection …

    View Full Text