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  • Review: Amantadine and rimantadine effectively prevent and treat influenza in healthy adults, but rimantadine is better tolerated

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Therapeutics
Review: Amantadine and rimantadine effectively prevent and treat influenza in healthy adults, but rimantadine is better tolerated

https://doi.org/10.1136/ebm.4.6.184

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    Jefferson TO, Demicheli V, Deeks JJ, Rivetti D. Amantadine and rimanta-dine for preventing and treating influenza A in adults. Cochrane Review, latest version 19 Feb 1999. In: The Cochrane Library. Oxford: Update Software.

    Question

    What are the effectiveness and safety of amantadine and rimantadine for preventing and treating influenza in adults?

    Data sources

    Studies were identified from the Cochrane Controlled Trials Register, MEDLINE, and EMBASE/Excerpta Medica databases; bibliographies of relevant papers; and contact with authors, researchers, and drug manufacturers.

    Study selection

    Studies were selected if they were randomized controlled trials (RCTs) or quasi-randomized trials of healthy adults between 14 and 60 years of age. Inclusion criteria were comparison of amantadine, rimantadine, or both with placebo, control antiviral agents, or no intervention; and comparison of doses or schedules of amantadine, rimanta-dine, or both for the prevention or treatment of influenza.

    Data extraction

    Data were extracted on study and participant characteristics, interventions, number and severity of influenza cases, death, and adverse …

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