You are here

Article Text

Article menu
Therapeutics
Continuous terbinafine was more effective than intermittent itraconazole for curing toenail onychomycosis

https://doi.org/10.1136/ebm.4.6.187

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Evans EG, Sigurgeirsson B, for the LION Study Group. Double blind, randomised study of continuous terbinafine compared with intermittent itraconazole in treatment of toenail onychomycosis. BMJ. 1999 Apr 17;318:1031-5.

    Question

    In patients with toenail onychomy-cosis, does continuous terbinafine heal infection better than intermittent itraconazole?

    Design

    Randomised (concealed), blinded (patients and outcome assessors), controlled trial with 72-week follow-up.

    Setting

    35 centres in 6 countries (Finland, Germany, Iceland, Italy, the Netherlands, and the United Kingdom).

    Patients

    507 patients who were 18 to 75 years of age and had a clinical, mycologically confirmed diagnosis of toenail onychomycosis with an affected great toenail capable of regrowth. Exclusion criteria included infections other than dermatophyte infection; use of systemic or topical antifungal treatment within the previous 12 months and 4 weeks, respectively; use of drugs that might interact with study drugs; systemic conditions that might alter the pharmacodynamics of study drugs; …

    View Full Text