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Mortality rates were higher in adults with epilepsy, but the risk for dying directly of epilepsy was small

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Shackleton DP, Westendorp RG, Kasteleijn-Nolst Trenité DG, Vanden-broucke JP. Mortality in patients with epilepsy: 40 years of follow up in a Dutch cohort study. J Neurol Neurosurg Psychiatry. 1999 May;66: 636-40.


In adults with newly diagnosed epilepsy, are all-cause mortality and epilepsy-specific mortality increased during short-term and long-term follow-up?


Inception cohort followed for up to 41 years (mean 28 y).


Community- and hospital-based epilepsy institute in the Netherlands.


1455 patients (54% men) with newly diagnosed epilepsy who first visited the institute between 1953 and 1967. Mean age at diagnosis was 19 years (range 6 mo to 70 y). Follow-up was 93% (1355 patients, 55% men). A neurologist confirmed epilepsy by using patient history and the results of electroencepha-lography. Exclusion criterion was pre-vious remote, symptomatic, unprovoked seizures.

Assessment of prognostic factors

Age, age at diagnosis, sex, date of first hospitalization in the epilepsy institute, and duration of disease.

Main outcome measures

Mortality was categorized …

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