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Dixon JM, McDonald C, Elton RA, Miller WR, for the Edinburgh Breast Group. Risk of breast cancer in women with palpable breast cysts: a prospective study. Lancet. 1999 May 22;353:1742-5.
Questions
Do women with palpable breast cysts have a greater risk for breast cancer? Is cyst type associated with risk for breast cancer?
Design
Cohort study with median follow-up of 5 years for women who developed breast cancer and 10 years for women who did not.
Setting
Edinburgh Breast Unit, Scotland, United Kingdom.
Participants
Complete data were available for 1334 of 1374 women with palpable breast cysts (54% type I, 33% type II, and 13% mixture).
Assessment of risk factors
Type of cyst (Na+K+ ratio < 3 for type I cysts and 3 for type II cysts), num ber of cysts, age, and length of time after cyst aspiration.
Main outcome measures
Incidence of breast cancer was assessed by …