You are here

Article Text

Article menu
Download PDFPDF
Therapeutics
Spironolactone reduced mortality in severe congestive heart failure

https://doi.org/10.1136/ebm.5.1.11

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    (1999) N Engl J Med 341, 709. Pitt B, Zannad F, Remme WJ, et al. for the Randomized Aldactone Evaluation Study Investigators. . The effect of spironolactone on morbidity and mortality in patients with severe heart failure. . . Sep 2;. :. –17.
    OpenUrlCrossRefPubMedWeb of Science

    
 
 QUESTION: In patients with severe congestive heart failure (CHF) caused by systolic left ventricular dysfunction, does spironolactone combined with usual care reduce all-cause mortality?

    Design

    Randomised (allocation concealed*), blinded (patients, clinicians, and outcome assessors),* placebo-controlled trial with mean follow-up of 24 months. Interim analyses were done.

    Setting

    195 clinical centres in 15 countries.

    Patients

    1663 patients (mean age 65 y, 73% men, 87% white) with severe CHF who were using angiotensin-converting enzyme (ACE) inhibitors, if tolerated, and a loop diuretic and had had a recent left ventricular ejection fraction ≤35%. The major exclusion criterion was use of potassium-sparing diuretics. All patients were analysed.

    Intervention

    All patients received usual care and were allocated to spironolactone, 25 mg/day, which could be doubled after 8 weeks …

    View Full Text