You are here

Article Text

Article menu
Download PDFPDF
Therapeutics
n-3 polyunsaturated fatty acids reduced mortality and morbidity after recent myocardial infarction

https://doi.org/10.1136/ebm.5.1.13

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    (1999) Lancet 354, 447. GISSI-Prevenzione Investigators.. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial.. Aug 7;. :. –55.
    OpenUrlCrossRefPubMedWeb of Science

    
 
 QUESTION: In patients with recent myocardial infarction (MI), are n-3 polyunsaturated fatty acids (PUFAs) and vitamin E, singly or in combination, effective for reducing morbidity and mortality?

    Design

    Randomised (allocation concealed*), blinded (outcome assessors),* controlled trial with 42 month follow-up.

    Setting

    Centres in Italy.

    Patients

    11 324 patients (51% ⩽60 y of age, 85% men) with recent MI (within previous 3 mo) who had no contraindications to the study dietary supplements and no conditions with unfavorable short-term prognoses. Follow-up was 99.9%.

    Intervention

    Patients were allocated to n-3 PUFAs (n=2836), vitamin E (n=2830), n-3 PUFAs and vitamin E (n=2830), or no supplement (n=2828). n-3 PUFA was given in 1 gelatin capsule containing eicosa-pentaenoic acid, 850–882 …

    View Full Text

    Footnotes

    • Sources of funding: Bristol-Myers Squibb; Pfizer; Pharmacia-Upjohn; Società Proditti Antibiotici.

    • For correspondence: Dr R Marchioli, GISSI-Prevenzione Coordinating Centre, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro, Italy. FAX +39-0872-578240.

    • ↵* See glossary.

    • ↵† p value calculated from data in article.