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Inhaled budesonide plus oral prednisone reduced relapse after discharge from the emergency department for acute asthma

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 QUESTION: In patients discharged from the emergency department (ED) with acute asthma, does the addition of inhaled budesonide to a fixed dose of oral prednisone reduce relapses?


Randomised (allocation concealed*), blinded (patients and outcome assessors),* placebo-controlled trial with 21-day follow-up.


A community hospital ED in Sudbury, Ontario, Canada.


191 patients 16–60 years of age who were treated in the ED for acute asthma and had a peak expiratory flow rate <80% predicted for sex, age, and height. Patients were excluded if they had received oral or inhaled corticosteroids during the previous week. Follow-up was 94%.


All patients were given a non-tapering, 7-day course of oral prednisone, 50 mg/day, at discharge. 94 patients were allocated to an inhaled budesonide …

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