You are here

  • Home
  • Archive
  • Volume 5, Issue 1
  • Review: aspirin reduces the risk for stroke in patients with previous transient ischaemic attack or stroke but does not have a dose-response effect

Article Text

Article menu
Download PDFPDF
Therapeutics
Review: aspirin reduces the risk for stroke in patients with previous transient ischaemic attack or stroke but does not have a dose-response effect

https://doi.org/10.1136/ebm.5.1.9

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    (1999) Arch Intern Med 159, 1248. Johnson ES, Lanes SF, Wentworth CE 3d, et al.. A metaregression analysis of the dose-response effect of aspirin on stroke.. Jun 14;. :. –53.
    OpenUrlCrossRefPubMedWeb of Science

    
 
 QUESTION: In patients with a previous transient ischaemic attack (TIA) or stroke, does a dose-response relation exist for aspirin use and the risk for stroke?

    Data sources

    Studies were identified by searching Medline (to April 1996) and by scanning reference lists of relevant articles.

    Study selection

    Studies were selected if they were randomised, placebo-controlled, secondary prevention trials that included a comparison of aspirin alone and reported stroke as an outcome.

    Data extraction

    2 reviewers extracted published data on demographics, inclusion and exclusion criteria, treatment regimen, duration of follow-up, and all strokes (ischaemic and haemorrhagic). Another reviewer independently extracted data on outcomes, inclusion and exclusion criteria, and health status at entry.

    Main results

    11 randomised controlled trials met the selection criteria (9629 patients [5228 allocated to aspirin and 4401 to placebo], mean age 63 y, …

    View Full Text

    Footnotes

    • Source of funding: Boehringer Ingelheim.

    • For correspondence: Mr E S Johnson, Epidemiology Resources Inc. 1 Newton Executive Park, Newton Lower Falls, MA 02162, USA. FAX 617-244-9669.