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  • Review: penicillin V or amoxicillin is better than placebo and equal to non-penicillins for acute maxillary sinusitis

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Therapeutics
Review: penicillin V or amoxicillin is better than placebo and equal to non-penicillins for acute maxillary sinusitis

https://doi.org/10.1136/ebm.5.2.43

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    . Williams JW Jr, Aguilar C, Makela M, et al. Antimicrobial therapy for acute maxillary sinusitis. Cochrane Review, latest version 26 May 1999. In: the Cochrane Library. Oxford: Update Software..

    
 
 QUESTION: Which antibiotics lead to higher clinical cure rates in adults with acute maxillary sinusitis?

    Data sources

    Studies were identified by searching Medline and EMBASE/Excerpta Medica (to October 1998), scanning bibliographies of relevant articles, and contacting pharmaceutical companies and experts in the field.

    Study selection

    Studies were selected if they were randomised controlled trials (RCTs) that compared an antibiotic with placebo or with another type of antibiotic in ≥30 patients who were ≥18 years of age and had a history consistent with acute maxillary sinusitis confirmed by radiography or aspiration.

    Data extraction

    2 or more reviewers independently extracted data on study characteristics; interventions; study duration; length of follow-up; co-interventions; compliance; and clinical, bacteriological, radiographic, and adverse event …

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    Footnotes

    • Source of funding: no external funding.

    • For correspondence: Dr J Williams Jr, South Texas Veterans Health Care System, Audie Murphy Division, 7400 Merton Minter Boulevard, San Antonio, Texas 78284, USA.

    • A modified version of the abstract also appears in Evidence-Based Nursing