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  • Gemfibrozil reduced the risk for coronary events in men with coronary artery disease and low levels of high density lipoprotein cholesterol

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Therapeutics
Gemfibrozil reduced the risk for coronary events in men with coronary artery disease and low levels of high density lipoprotein cholesterol

https://doi.org/10.1136/ebm.5.2.49

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    (1999) N Engl J Med 341, 410. Rubins HB, Robins SJ, Collins D, et al,. for the Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group.. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol.. Aug 5;. :. –18.
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 QUESTION: Is gemfibrozil effective for secondary prevention of coronary artery disease (CAD) events in men with low levels of both high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol?

    Design

    Randomised {allocation concealed*},† blinded (patients, outcome assessors, and study personnel),* placebo controlled trial with median follow up of 5.1 years (Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial [VA-HIT]).

    Setting

    20 Veterans Affairs medical centres in the United States.

    Patients

    2531 men who were <74 years of age (mean age 64 y); had a documented history of CAD; had no serious comorbid conditions; and had an HDL cholesterol level ≤40 mg/dl (1.0 mmol/l), an LDL cholesterol level ≤140 mg/dl (3.6 mmol/l), and a triglyceride level ≤300 mg/dl …

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    Footnotes

    • Sources of funding: Veterans Affairs Office of Research and Development and Parke-Davis.

    • For correspondence: Dr HB Rubins, Section of General Internal Medicine (111O), Veterans Affairs Medical Center, Minneapolis, MN 55417, USA. Fax +1 612 725 2118.

    • ↵* See glossary.

    • ↵† Information provided by author.