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  • Empirical eradication therapy was better than endoscopy based management for Helicobacter pylori infection and dyspepsia

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Therapeutics
Empirical eradication therapy was better than endoscopy based management for Helicobacter pylori infection and dyspepsia

https://doi.org/10.1136/ebm.5.2.50

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    (1999) Gut 45, 186; Heaney A, Collins JS, Watson RG, et al.. A prospective randomised trial of a “test and treat” policy versus endoscopy based management in young Helicobacter pylori positive patients with ulcer-like dyspepsia, referred to a hospital clinic.. Aug;. :. –90.
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 QUESTION: In younger patients with Helicobacter pylori infection and dyspepsia, is empirical eradication therapy better than an endoscopy based management strategy for reducing dyspepsia and improving quality of life?

    Design

    Randomised (unclear allocation concealment*), unblinded,* controlled trial with 12 month follow up.

    Setting

    Gastroenterology clinics of 2 hospitals in Belfast, Northern Ireland, United Kingdom.

    Patients

    104 patients who had ulcer-like dyspepsia and were ≤45 years of age (mean age 32 y, 57% men). Exclusion criteria were weight loss, dysphagia, symptoms of gastroesophageal reflux disease, history of gastrointestinal bleeding, regular use of non-steroidal anti-inflammatory drugs, gallstone symptoms, pregnancy, and H. pylori eradication treatment in the previous 2 weeks. Follow up was …

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    Footnotes

    • Source of funding: not stated.

    • For correspondence: Dr A Heaney, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland, UK.

    • ↵* See glossary.