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Therapeutics
Methylprednisolone injection improved symptoms for 1 year in patients with the carpal tunnel syndrome

https://doi.org/10.1136/ebm.5.2.52

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    (1999) BMJ 319, 884. Dammers JW, Veering MM, Vermeulen M.. Injection with methylprednisolone proximal to the carpal tunnel: randomised double blind trial.. Oct 2;. :. –6.
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 QUESTION: What is the effectiveness of a methylprednisolone injection in patients with the carpal tunnel syndrome?

    Design

    Randomised (allocation concealed*), blinded (clinician, patient, and outcome assessor),* placebo controlled trial with 1 year follow up.

    Setting

    Outpatient neurology clinic in a district general hospital in the Netherlands.

    Patients

    Patients >18 years of age (mean age 52 y, 83% women) who had signs and symptoms of the carpal tunnel syndrome for ≥3 months confirmed by electrophysiological tests. Patients who had already been treated for the carpal tunnel syndrome were excluded. Follow up was 100%.

    Intervention

    Patients were allocated to receive a single injection of methylprednisolone, 40 mg, and lignocaine, 10 mg (intervention …

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    Footnotes

    • Source of funding: no external funding.

    • For correspondence: Dr J W Dammers, Department of Neurology, Medical Centre Alkmaar, PO Box 501, 1800 AM Alkmaar, the Netherlands.

    • ↵* See glossary.