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Therapeutics
Raloxifene reduced vertebral fractures in postmenopausal women

https://doi.org/10.1136/ebm.5.2.54

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    (1999) JAMA 282, 637. Ettinger B, Black DM, Mitlak BH, et al,. for the Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators.. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene. Results from a 3-year randomized clinical trial.. Aug 18;. :. –45.
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 QUESTION: In postmenopausal women with osteoporosis, does raloxifene reduce the rate of vertebral and non-vertebral fractures?

    Design

    Randomised (allocation concealed*), blinded (patients, clinicians, and outcome assessors),* placebo controlled trial.

    Setting

    180 clinical centres in 25 countries.

    Participants

    7705 postmenopausal women (mean age 67 y, 96% white) with osteoporosis. Exclusion criteria included other bone diseases, postmenopausal symptoms, abnormal uterine bleeding, history of breast or endometrial cancer or thromboembolic disorders, other cancers, treated endocrine disorders except type 2 diabetes or hypothyroidism, renal lithiasis, abnormal hepatic or renal function, untreated malabsorption, and consumption of >4 drinks of alcohol/d. Follow up was 89%.

    Intervention

    Women received calcium, 500 mg/d, and cholecalciferol, 400 to 600 IU/d, and were allocated …

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    Footnotes

    • Source of funding: Eli Lilly and Company.

    • For correspondence: Dr B Ettinger, Division of Research, Kaiser Permanente Medical Care Program, 3505 Broadway, 13th Floor, Oakland, CA 94611-5400, USA. Fax +1 510 450 2097.

    • ↵* See glossary.