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Therapeutics
Omeprazole was better than cisapride or placebo for controlling heartburn at 4 and 8 weeks

https://doi.org/10.1136/ebm.5.2.59

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    (1999) BMJ 319, 550. Hatlebakk JG, Hyggen A, Madsen PH, et al,. on behalf of the Norwegian Heartburn Study Group.. Heartburn treatment in primary care: randomised, double blind study for 8 weeks.. Aug 28;. :. –3.
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 QUESTION: In patients with heartburn, are omeprazole and cisapride effective for controlling symptoms?

    Design

    8 week randomised (allocation concealed*), blinded (patients and outcome assessors),* controlled trial.

    Setting

    65 primary care practices in liaison with endoscopy units and pharmacies in Norway.

    Patients

    {484}† patients who were 18 to 80 years of age (median age 47 y in the cisapride group, 49 y in the omeprazole group, 50 y in the placebo group; 52% men) and had had heartburn for ≥3 d/wk for ≥3 months during a 14 day run in period. Exclusion criteria were grade 2 or 3 oesophagitis; Barrett oesophagus; peptic ulcer disease; gallstone disease; oesophagogastric surgery; use of prokinetic, …

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    Footnotes

    • Source of funding: Astra Norge.

    • For correspondence: Dr J G Hatlebakk, Department of Medicine, Haukeland Sykehus, University of Bergen, N-5021 Bergen, Norway. Fax +47 55 97 2950.

    • ↵* See glossary.

    • ↵† Additional information supplied by the BMJ website (http://www.bmj.com).