Article Text

Download PDFPDF
Omeprazole was better than cisapride or placebo for controlling heartburn at 4 and 8 weeks

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

 QUESTION: In patients with heartburn, are omeprazole and cisapride effective for controlling symptoms?


8 week randomised (allocation concealed*), blinded (patients and outcome assessors),* controlled trial.


65 primary care practices in liaison with endoscopy units and pharmacies in Norway.


{484} patients who were 18 to 80 years of age (median age 47 y in the cisapride group, 49 y in the omeprazole group, 50 y in the placebo group; 52% men) and had had heartburn for ≥3 d/wk for ≥3 months during a 14 day run in period. Exclusion criteria were grade 2 or 3 oesophagitis; Barrett oesophagus; peptic ulcer disease; gallstone disease; oesophagogastric surgery; use of prokinetic, …

View Full Text


  • Source of funding: Astra Norge.

  • For correspondence: Dr J G Hatlebakk, Department of Medicine, Haukeland Sykehus, University of Bergen, N-5021 Bergen, Norway. Fax +47 55 97 2950.

  • * See glossary.

  • Additional information supplied by the BMJ website (