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Omeprazole was better than cisapride or placebo for controlling heartburn at 4 and 8 weeks
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 QUESTION: In patients with heartburn, are omeprazole and cisapride effective for controlling symptoms?

Design

8 week randomised (allocation concealed*), blinded (patients and outcome assessors),* controlled trial.

Setting

65 primary care practices in liaison with endoscopy units and pharmacies in Norway.

Patients

{484} patients who were 18 to 80 years of age (median age 47 y in the cisapride group, 49 y in the omeprazole group, 50 y in the placebo group; 52% men) and had had heartburn for ≥3 d/wk for ≥3 months during a 14 day run in period. Exclusion criteria were grade 2 or 3 oesophagitis; Barrett oesophagus; peptic ulcer disease; gallstone disease; oesophagogastric surgery; use of prokinetic, …

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