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Hyaluronic acid improved walking ability and short term knee function in osteoarthritis of the knee

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 QUESTION: In patients with osteoarthritis of the knee, is hyaluronic acid (HA) effective for relieving symptoms?


Randomised (unclear allocation concealment*), blinded (outcome assessor and {patients}),* placebo controlled trial with 6 month follow up.


A hospital outpatient clinic in London, UK.


100 patients (mean age 65 y, 67% women) who had osteoarthritis of 1 or both knees according to the criteria of the American Rheumatism Association, changes in osteoarthritis (Kellgren and Lawrence grade II or III) on radiography in the previous 6 months, consistent pain in the previous 3 months, and moderate or severe pain on walking. Exclusion criteria were grade …

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  • Source of funding: no external funding.

  • For correspondence: Dr S Donnelly, Department of Rheumatology, Whipps Cross Hospital, London E11 1NR, UK. Fax +44 (0)20 8558 8115.

  • * See glossary.

  • Information supplied by author.