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Therapeutics
Hyaluronic acid improved walking ability and short term knee function in osteoarthritis of the knee

https://doi.org/10.1136/ebm.5.3.73

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    (1999) Rheumatology 38, 602. Huskisson EC, Donnelly S.. Hyaluronic acid in the treatment of osteoarthritis of the knee. Jul;. :. –7.
    OpenUrlAbstract/FREE Full Text

    
 
 QUESTION: In patients with osteoarthritis of the knee, is hyaluronic acid (HA) effective for relieving symptoms?

    Design

    Randomised (unclear allocation concealment*), blinded (outcome assessor and {patients}†),* placebo controlled trial with 6 month follow up.

    Setting

    A hospital outpatient clinic in London, UK.

    Patients

    100 patients (mean age 65 y, 67% women) who had osteoarthritis of 1 or both knees according to the criteria of the American Rheumatism Association, changes in osteoarthritis (Kellgren and Lawrence grade II or III) on radiography in the previous 6 months, consistent pain in the previous 3 months, and moderate or severe pain on walking. Exclusion criteria were grade …

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    Footnotes

    • Source of funding: no external funding.

    • For correspondence: Dr S Donnelly, Department of Rheumatology, Whipps Cross Hospital, London E11 1NR, UK. Fax +44 (0)20 8558 8115.

    • ↵* See glossary.

    • ↵† Information supplied by author.