You are here

Article Text

Article menu
Download PDFPDF
Therapeutics
Conventional and newer antihypertensive drugs had similar efficacy in elderly people with hypertension

https://doi.org/10.1136/ebm.5.3.85

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    (1999) Lancet 354, 1751. Hansson L, Lindholm LH, Ekbom T, et al,. for the STOP-Hypertension-2 study group.. Randomised trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 study.. Nov 20;. :. –6.
    OpenUrlCrossRefPubMedWeb of Science

    
 
 QUESTION: In elderly people with hypertension, are newer antihypertensive drugs as effective as conventional antihypertensive drugs for reducing cardiovascular events?

    Design

    Randomised {allocation concealed*}†, blinded (outcome assessors),* controlled trial with 4 year follow up.

    Setting

    312 health centres in Sweden.

    Patients

    6614 patients who were 70 to 84 years of age (mean age 76 y, 67% women) and had hypertension (defined as systolic blood pressure ≥180 mm Hg or diastolic blood pressure ≥105 mm Hg or both). Follow up was 100%.

    Intervention

    Patients were allocated to 1 of 3 groups: conventional antihypertensive drugs (atenolol, 50 mg/d; metoprolol, 100 mg/d; pindolol, 5 mg/d; or fixed ratio hydrochlorothiazide, 25 mg/d, and amiloride, 2.5 mg/d) (n=2213); angiotensin converting enzyme (ACE) …

    View Full Text

    Footnotes

    • Sources of funding: Astra; Merck Sharp and Dohme; Sandoz; Zeneca.

    • For correspondence: Professor L Hansson, Department of Public Health and Social Sciences, University of Uppsala, PO Box 609, 75125 Uppsala, Sweden. Fax +46 18 177973.

    • ↵* See glossary.

    • ↵† Information provided by author.