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Therapeutics
Paroxetine was effective for reducing symptoms in social phobia

https://doi.org/10.1136/ebm.5.3.86

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    (1999) Br J Psychiatry 175, 120. Baldwin D, Bobes J, Stein DJ, et al,. on behalf of the Paroxetine Study Group.. Paroxetine in social phobia/social anxiety disorder. Randomised, double-blind, placebo-controlled study.. Aug;. :. –6.
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 QUESTION: In patients with social phobia, is paroxetine effective for reducing symptoms?

    Design

    Randomised {allocation concealed*}†, blinded {clinicians, patients, outcome assessors, and statisticians}*†, placebo controlled trial with 12 week follow up.

    Setting

    39 centres in Belgium, France, Germany, Ireland, South Africa, Spain, and the United Kingdom.

    Patients

    290 patients who were ≥18 years of age (mean age 36 y, 54% women) and had a primary diagnosis of social phobia according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria. Exclusion criteria included any other recent Axis 1 disorder, serious medical disorders, or recent use of psychotropic drugs or psychotherapy. 73% of patients completed the study, and 97% were analysed.

    Intervention

    Patients were allocated to paroxetine, 20 mg/day initially and increased …

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    Footnotes

    • Source of funding: SmithKline Beecham Pharmaceuticals.

    • For correspondence: Dr D Baldwin, Mental Health Group, University of Southampton, Royal South Hants Hospital, Brintons Terrace, Southampton SO14 0YG, UK. Fax +44 (0)1703 234243.

    • ↵* See glossary.

    • ↵† Information supplied by author.

    • ↵‡ Difference in mean change and CI calculated from data in article.