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Paroxetine was effective for reducing symptoms in social phobia

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 QUESTION: In patients with social phobia, is paroxetine effective for reducing symptoms?


Randomised {allocation concealed*}, blinded {clinicians, patients, outcome assessors, and statisticians}*, placebo controlled trial with 12 week follow up.


39 centres in Belgium, France, Germany, Ireland, South Africa, Spain, and the United Kingdom.


290 patients who were ≥18 years of age (mean age 36 y, 54% women) and had a primary diagnosis of social phobia according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria. Exclusion criteria included any other recent Axis 1 disorder, serious medical disorders, or recent use of psychotropic drugs or psychotherapy. 73% of patients completed the study, and 97% were analysed.


Patients were allocated to paroxetine, 20 mg/day initially and increased …

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  • Source of funding: SmithKline Beecham Pharmaceuticals.

  • For correspondence: Dr D Baldwin, Mental Health Group, University of Southampton, Royal South Hants Hospital, Brintons Terrace, Southampton SO14 0YG, UK. Fax +44 (0)1703 234243.

  • * See glossary.

  • Information supplied by author.

  • Difference in mean change and CI calculated from data in article.