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Antidepressants plus cognitive therapy reduced relapse in residual depression

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 QUESTION: In patients with residual depressive symptoms who continue to receive maintenance antidepressant treatment, does cognitive therapy (CT) reduce relapse rates?


Randomised {allocation concealed*}, blinded (outcome assessors),*r; controlled trial with 1 year follow up.


2 psychiatric outpatient clinics, Cambridge and Newcastle, UK.


158 patients between 21 and 65 years of age (mean age 43 y, 51% men) with unipolar depression, satisfying the Diagnostic and Statistical Manual of Mental Disorders, 3d edition, Revised (DSM-III-R) criteria for major depression within the previous 18 months but not in the previous 2 months, and who had residual symptoms (lasting 2 to 18 mo) reaching at least 8 on the 17 item Hamilton Depression Rating Scale and 9 on the Beck Depression Inventory. Exclusion criteria were history of bipolar disorders, cyclothymia, schizoaffective disorder, drug or alcohol dependence, …

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