Article Text

Download PDFPDF
Review: oral Haemophilus influenzae vaccination reduces the number and severity of recurrent bronchitis episodes

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

 QUESTION: Does an oral, whole cell, non-typeable Haemophilus influenzae (NTHi) vaccine protect against recurrent episodes of acute bronchitis?

Data sources

Studies were identified by searching Medline (1965–98), Extramed (1994–8), ISI Current Contents (1993–8), Carl Uncover (1988–98), and the Cochrane Controlled Trials Register with the terms bronchitis, haemophilus, vaccine, bronchostat, and bucaline burna; by scanning relevant books, bibliographies of articles, and conference abstracts; and by contacting authors and experts in the field.

Study selection

Published studies were selected if they were randomised controlled trials that compared the effects of oral monobacterial NTHi vaccination with placebo in patients between 19 and 93 years of age who had recurrent exacerbations of acute bronchitis or chronic obstructive pulmonary disease; patients in vaccine and …

View Full Text


  • Source of funding: no external funding.

  • For correspondence: Dr R Foxwell, Division of Science & Design, University of Canberra, ACT, Australia 2601. Fax +61 2 6201 2461.