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QUESTION: Does an oral, whole cell, non-typeable Haemophilus influenzae (NTHi) vaccine protect against recurrent episodes of acute bronchitis?
Studies were identified by searching Medline (1965–98), Extramed (1994–8), ISI Current Contents (1993–8), Carl Uncover (1988–98), and the Cochrane Controlled Trials Register with the terms bronchitis, haemophilus, vaccine, bronchostat, and bucaline burna; by scanning relevant books, bibliographies of articles, and conference abstracts; and by contacting authors and experts in the field.
Published studies were selected if they were randomised controlled trials that compared the effects of oral monobacterial NTHi vaccination with placebo in patients between 19 and 93 years of age who had recurrent exacerbations of acute bronchitis or chronic obstructive pulmonary disease; patients in vaccine and …
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