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  • Oral montelukast was better than inhaled salmeterol for reducing exercise induced bronchoconstriction in adults with asthma

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Therapeutics
Oral montelukast was better than inhaled salmeterol for reducing exercise induced bronchoconstriction in adults with asthma

https://doi.org/10.1136/ebm.5.4.109

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    (2000) Ann Intern Med 132, 97. Edelman JM, Turpin JA, Bronsky EA. , et al, for the Exercise Study Group.. Oral montelukast compared with inhaled salmeterol to prevent exercise-induced bronchoconstriction.. Jan 18;. :. –104.
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 QUESTION: Is oral montelukast as effective as inhaled salmeterol for prevention of exercise induced bronchoconstriction (EIB) in adults with asthma?

    Design

    8 week, randomised {allocation concealed*}†, blinded {patients, clinicians, outcome assessors, statisticians},*† controlled trial.

    Setting

    17 asthma treatment centres in the US.

    Patients

    191 patients who were 15–45 years of age (mean age 26 y, 52% men), had a history of chronic asthma, had an FEV1 ≥65% of the predicted value at rest, and had a decrease in FEV1 ≥20% after a standardised exercise challenge on 2 occasions during baseline measurement. Exclusion criteria were upper respiratory infection or exacerbation of asthma that had required emergency care in the previous month or admission to hospital for asthma in the previous …

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    Footnotes

    • Source of funding: Merck and Company, Inc.

    • For correspondence: Dr J M Edelman, Merck and Company, Inc., Box 4, HM-220, West Point, PA 19486, USA. Fax +1 215 328 2444.

    • ↵* See glossary.

    • ↵† Data provided by author.