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High dose lisinopril was more effective than low dose for reducing combined mortality and cardiovascular events in congestive heart failure
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 QUESTION: In patients with congestive heart failure (CHF), is high dose lisinopril more effective than low dose lisinopril for reducing mortality and admission to hospital rates?

Design

Randomised (allocation concealment unclear*), blinded (patients, investigators, and outcome assessors),* controlled trial with 3 year follow up.

Setting

287 hospitals in 19 countries.

Patients

3793 patients were screened, and 3164 (mean age 63.6 y, 80% men) were studied. Inclusion criteria were New York Heart Association class II, III, or IV CHF, despite use of diuretics for ≥2 months, and left ventricular ejection fraction ≤30%. Exclusion criteria were recent revascularisation procedure or ischaemic event, history of ventricular tachycardia, intolerance to angiotensin converting enzyme (ACE) inhibitors, serum creatinine levels >2.5 mg/dl, or non-cardiac disorders that could limit survival. Follow up was 100%.

Intervention

Patients received their usual CHF medications …

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