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Low volume, high frequency cows' milk feedings sped recovery from diarrhoea in infants

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 QUESTION: In infants with acute diarrhoea, do more frequent, low volume feedings of cows' milk promote faster recovery than less frequent, high volume feedings of the same total volume of cows' milk?


14 day randomised (unclear allocation concealment*), unblinded,* controlled trial.


4 tertiary care hospitals in Chengdu, China.


282 boys who were 3–12 months of age and had acute diarrhoea and mild to severe dehydration. Exclusion criteria were malnutrition, exclusive breast feeding, systematic infections (eg, pneumonia or septicaemia), or other diseases requiring additional treatments. Only boys were enrolled to facilitate the separation of urine and stool. 262 boys (93%) (mean age 8 mo) completed the study.


Infants were stratified by hospital and initial hydration status and allocated exclusively to cows' milk, either 18 ml/kg of body …

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  • Source of funding: International Clinical Epidemiology Network (INCLEN).

  • For correspondence: Dr C Wan, Departments of Pediatrics and Clinical Epidemiology, West China University of Medical Sciences, Chengdu 610041, People's Republic of China.

  • * See glossary.