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Lactobacillus GG reduced diarrhoea incidence in children treated with antibiotics

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 QUESTION: In children being treated with antibiotics, does co-administration of Lactobacillus GG (LGG) reduce the incidence of diarrhoea?


Randomised (allocation concealed*), blinded (clinicians, patients, and outcome assessors),* placebo controlled trial with 10 day follow up.


Primary care paediatric practice in Rapid City, South Dakota, United States.


202 children between 6 months and 10 years of age who had an acute infection of the upper or lower respiratory tract, urinary tract, soft tissues, or skin and were prescribed a 10 day course of antibiotics. Exclusion criteria were chronic disease, serious acute infection, or diarrhoea at the start of antibiotic administration. 188 children (93%) (median age 4 y, 55% girls) completed the study.


Children were allocated to LGG …

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  • Source of funding: ConAgra, Inc.

  • For correspondence: Dr J A Vanderhoof, University Medical Associates, 985160 NE Medical Center, University of Nebraska, Omaha, NE 68198-5160, USA. Fax +1 402 559 2412.

  • A modified version of the abstract also appears in Evidence-Based Nursing.

  • * See glossary.

  • p Value calculated from data in article.